Evaluation of GELTAMO-IPI for Patients with Diffuse Large B-cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2021.01.016
- Author:
Yao-Xu FENG
1
;
Li-Ping SU
2
Author Information
1. Graduate School of Shanxi Medical University,Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030000, Shanxi Province, China.
2. Department of Hematology, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030000, Shanxi Province, China,E-mail: Sulp2005@sohu.com.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
Humans;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Prognosis;
Retrospective Studies;
Risk Factors
- From:
Journal of Experimental Hematology
2021;29(1):98-103
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the prognostic value of GELTAMO-IPI for patients with diffuse large B-cell lymphoma (DLBCL).
METHODS:The clinical data of 238 newly diagnosed DLBCL patients treated in Shanxi Cancer Hospital from September 2011 to March 2016 were collected retrospectively, the risk stratification and prognostic evaluation of the patients were analyzed according to GELTAMO-IPI. Progression-free survival (PFS) and overall survival (OS) of the patients were analyzed by the Kaplan-Meier method, COX regression analysis was used to compare the risk of death and progress in each risk group. Harrell's C statistics was used to compare the prognostic stratification ability of each model.
RESULTS:The 3-year OS rate statistics showed that both IPI and GELTAMO-IPI could distinguish low risk group and Low-intermediate risk group, but the prognosis stratification ability of IPI was better (IPI: HR=5.085, P<0.05; GELTAMO-IPI; HR=4.639, P>0.05). GELTAMO-IPI could distinguish High-intermediate risk group from high risk group (GELTAMO-IPI: HR=2.966, P<0.05; 3 years OS rate was 34.5%), but the ability of IPI to identify high risk groups was weak (3 years OS>50%). The results of Harrell's C statistics showed the C-index of IPI and GELTAMO-IPI was 0.687 and 0.721 (P<0.001); the C-index of the predicted PFS was 0.672 and 0.700 (P<0.001). It was suggested that the prognostic stratification ability of GELTAM0-IPI be superior to that of IPI, R-IPI, NCCN-IPI.
CONCLUSION:GELTAMO-IPI can make a clear distinction between DLBCL patients with different prognosis, especially for high-risk patients, and the prognostic stratification ability of GELTAMO-IPI is significantly better than that of IPI.
