Level of Microparticles in Patients with Essential Thrombocythemia and Its Relation with JAK2V617F Mutation.
10.19746/j.cnki.issn.1009-2137.2020.06.041
- Author:
Shi-Xiang ZHAO
1
;
Tong-Hua YANG
2
;
Qiang PEI
3
;
Ren-Bin ZHAO
3
Author Information
1. Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China,Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.
2. Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China,E-mail：ynanblood@aliyun.com.
3. Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China.
- Publication Type:Journal Article
- MeSH:
Blood Platelets;
Cell-Derived Microparticles;
Endothelial Cells;
Humans;
Mutation;
Patients;
Thrombocythemia, Essential/genetics*
- From:
Journal of Experimental Hematology
2020;28(6):2046-2050
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the levels of microparticles (MP) in plasma of patients with esseutial thrombo-cythermia(ET) and analyze the relationship between the JAK2V617F mutant and MP in ET patients.
METHODS:The numerical values of MPs were analysed by using flow cytometry. Venous blood of 56 ET patients and 28 healthy persons was collected in the morning and anticoagulated with sodium citrate (1∶9). The RMP, PMP, TF
RESULTS:The detection results showed that the MP levels in ET group were higher than those in normal control group: RMP (157.2±304.9/μl vs 21.3±18.4/μl), PMP (1378.9±2454/μl vs 113.8±97.1/μl), TF
CONCLUSION:The numerical values of MP detected are more in ET patients than those in healthy controls. The number of MP is higher in patients with thrombus than that without thrombus, so do in patients with splenomegaly and without splenomegaly. Patients with JAK2V617F mutation show higher number of TF
