Clinical Value of Serum Amyloid A and Misfolded Transthyretin for Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients.
10.19746/j.cnki.issn.1009-2137.2020.06.022
- Author:
Hu LIU
1
;
Shu-Ling HOU
2
;
Shu-Ying LIU
3
;
Xi LI
1
;
Li LI
1
;
Ju-Ya CUI
1
;
Ke LIAN
1
;
Xiao-Bo WU
1
;
Gang-Gang WANG
1
;
Qiao-Hua ZHANG
1
Author Information
1. Department of Lymphoma, Shanxi Bethune Hospital, Taiyuan 030032, Shanxi Province, China.
2. Department of Lymphoma, Shanxi Bethune Hospital, Taiyuan 030032, Shanxi Province, China,E-mail: 13834134457@139.com.
3. Linfen Central Hospital, Linfen 041000, Shanxi Province, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
Humans;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Patients;
Prealbumin/therapeutic use*;
Prognosis;
Serum Amyloid A Protein
- From:
Journal of Experimental Hematology
2020;28(6):1923-1932
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the clinical value of serum amyloid A (SAA1/2) and misfolded transthyretin (TTR) for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) patients.
METHODS:30 R/R DLBCL patients were enrolled as observation group, 20 remission/stabilization DLBCL and 10 chronic lymphadenitis patients were enrolled as control group. SELDI technique, Tris-Tricine sodium dodecyl sulfate-polyacrylamide gel electro-phoresis, the shotgun-LTQ-MS method, and bioinformatics technique were used to detected and analyzed SAA and TTR in R/R DLBCL patients. SPSS 21.0 software was used to analyze the relationship between the high expression of SAA, misfolded TTR in serum and the clinicopathological features, survival time of R/R DLBCL. patients Chi-square test was used to analyze clinical count data, Kaplan-Meier curve was used for survival analysis, and Log-Rank test was used to compare single-factor survival differences.
RESULTS:The high expression of SAA and TTR (SAA
CONCLUSION:Both SAA and misfolded TTR are poor prognosis factors of R/R DLBCL patients.
