The Correlation of Minimal Residual Disease with Prognosis in TCF3-PBX1

Li Zhang; Yao Zou; Xiao-fei AI; Zeng Cao; Yu-mei Chen; Ye Guo; Wen-yu Yang; Xiao-juan Chen; Shu-chun Wang; Xiao-ming Liu; Min Ruan; Tian-feng Liu; Fang Liu; Ben-quan QI; Li-xian Chang; Wen-bin AN; Yuan-yuan Ren; Qing-hua LI; Xiao-fan Zhu

Return

The Correlation of Minimal Residual Disease with Prognosis in TCF3-PBX1

Author: Li ZHANG ¹ ; Yao ZOU ¹ ; Xiao-Fei AI ¹ ; Zeng CAO ¹ ; Yu-Mei CHEN ¹ ; Ye GUO ¹ ; Wen-Yu YANG ¹ ; Xiao-Juan CHEN ¹ ; Shu-Chun WANG ¹ ; Xiao-Ming LIU ¹ ; Min RUAN ¹ ; Tian-Feng LIU ¹ ; Fang LIU ¹ ; Ben-Quan QI ¹ ; Li-Xian CHANG ¹ ; Wen-Bin AN ¹ ; Yuan-Yuan REN ¹ ; Qing-Hua LI ¹ ; Xiao-Fan ZHU ²
Author Information

1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
2. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China E-mail: xfzhu@ihcams.ac.cn.
Publication Type:Journal Article
MeSH: Adolescent; Bone Marrow; Child; Child, Preschool; Female; Humans; Male; Neoplasm, Residual; Oncogene Proteins, Fusion/genetics*; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence
From: Journal of Experimental Hematology 2020;28(6):1831-1836
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate the consistency between FCM and PCR on the detecting of MRD in TCF3-PBX1
METHODS:55 cases of paediatric TCF3-PBX1
RESULTS:Among the 55 children with TCF3-PBX1
CONCLUSION:The detection result of MRD in TCF3-PBX1 detect by FCM and PCR shows better consistency. MRD positivity detected by FCM at the end of induction therapy (day 33) predicts a high risk of relapse in TCF3-PBX1 ALL patients.