Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing.
- Author:
Ru-Yue ZHENG
1
;
Shu-Juan WANG
1
;
Chong WANG
1
;
Tao LI
1
;
Lin-Xiao LIAO
1
;
Meng-Lin LI
1
;
Sheng-Mei CHEN
1
;
Rong GUO
1
;
Wei-Qiong WANG
1
;
Yu ZHANG
1
;
Yi FAN
1
;
Ding-Ming WAN
1
;
Yan-Fang LIU
2
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Humans; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Receptor, Notch1/genetics*; Sequence Analysis, DNA
- From: Journal of Experimental Hematology 2020;28(6):1791-1795
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the characteristics of gene mutation in adult ALL and its clinical significance.
METHODS:Clinical data of 134 primary adult ALL patients and DNA sequencing results of 16 kinds of gene mutation were collected. The characteristic of gene mutation and clinical significances were statistically analyzed.
RESULTS:In 31 cases of 134 ALL cases (23.13%) the gene mutations were detected as follows: 19 cases of 114 B-ALL cases (16.67%), 11 cases of 19 T-ALL cases (57.89%) and 1 case of T/B-ALL. The incidence of T-ALL gene mutation was significantly higher than that of B-ALL (χ
CONCLUSION:There may be multiple gene mutations in adult ALL patients. IL7R and NOTCH1 are the most common gene mutations and NOTCH1 mutation may indicate poor prognosis. Detection of gene mutations is helpful to understand the pathogenesis of ALL and evaluate the prognosis of adult ALL patients.
