Advances on molecular mechanism of hepatitis B virus-induced hepatocellular carcinoma.
10.3724/zdxbyxb-2021-0032
- Author:
Hua NARANMANDURA
1
,
2
;
Rui HAO
1
,
2
;
Lide SU
1
,
2
;
Qianqian WANG
1
,
2
;
Yiming SHAO
1
,
2
Author Information
1. College of Pharmaceutical Sciences，Inner Mongolia Medical University，Hohhot 010000，China
2. 2. School of Medicine，Zhejiang University，Hangzhou 310058，China.
- Publication Type:Journal Article
- Keywords:
Gene integration;
Gene mutation;
Hepatitis B virus;
Hepatitis B virus X protein;
Hepatocellular carcinoma;
Review
- MeSH:
Carcinoma, Hepatocellular;
Hepatitis B/complications*;
Hepatitis B virus/genetics*;
Hepatocytes;
Humans;
Liver Neoplasms
- From:
Journal of Zhejiang University. Medical sciences
2021;50(1):113-122
- CountryChina
- Language:English
-
Abstract:
The pathogenesis of hepatitis B virus （HBV）-associated hepatocellular carcinoma （HCC） is complicated with the crosstalk of multiple factors and the multi-step processes. The main mechanisms underlying the HBV-induced HCC include:①integration of HBV DNA into the host hepatocyte genome to alter gene function at the insertion site，resulting in host genome instability and expression of carcinogenic truncated proteins;②HBV gene mutations at S，C，and X coding regions in the genome;③HBV X gene-encoded HBx protein activates proto-oncogenes and inhibits tumor suppressor genes，leading to the HCC occurrence. In this article，the recent research progress on the molecular mechanism of HBV-induced HCC is comprehensively reviewed，so as to provide insights into the prevention，early prediction and postoperative adjuvant therapy of HCC.
