Interaction between RAS gene and lipid metabolism in cancer.
10.3724/zdxbyxb-2021-0054
- Author:
Junchen PAN
1
;
Mingquan ZHANG
1
;
Peng HUANG
1
Author Information
1. Cancer Center，Sun Yat-Sen University，Guangzhou 510060，China.
- Publication Type:Journal Article
- Keywords:
Lipid metabolism;
Review;
Therapy;
Tumor;
gene
- MeSH:
Genes, ras;
Humans;
Lipid Metabolism/genetics*;
Neoplasms/genetics*;
Signal Transduction;
ras Proteins/metabolism*
- From:
Journal of Zhejiang University. Medical sciences
2021;50(1):17-22
- CountryChina
- Language:English
-
Abstract:
The gene is frequently mutated and abnormally activated in many cancers，and plays an important role in cancer development. Metabolic reprogramming occurs in malignant tumors，which can be one of the key targets for anti-tumor therapy. gene can regulate lipid metabolism through AKT-mTORC1 single axis or multiple pathways，such as lipid synthesis pathways and degradation pathways. Similarly，lipid metabolism can also modify and activate RAS protein and its downstream signaling pathways. This article overviews the current research progress on the interaction between lipid metabolism and ，to provide insight in therapeutic strategies of lipid metabolism for -driven tumors.
