Effect of glutamine metabolism on chemoresistance and its mechanism in tumors.
10.3724/zdxbyxb-2021-0040
- Author:
Liyuan ZHU
1
;
Xinyang HU
1
;
Hongchuan JIN
1
Author Information
1. Zhejiang Provincial Key Laboratory of Biotherapy，Sir Run Run Shaw Hospital，Zhejiang University School of Medicine，Hangzhou 310016，China.
- Publication Type:Review
- Keywords:
Cell metabolism;
Drug resistance;
Glutamine;
Review;
Tumor
- MeSH:
Cell Line, Tumor;
Drug Resistance, Neoplasm;
Glutamine/metabolism*;
Glycolysis;
Humans;
Neoplasms/drug therapy*;
Oxidative Phosphorylation;
Tumor Microenvironment
- From:
Journal of Zhejiang University. Medical sciences
2021;50(1):32-40
- CountryChina
- Language:English
-
Abstract:
The metabolic reprogramming of tumor cells is characterized by increased uptake of various nutrients including glutamine. Glutamine metabolism provides the required substances for glycolysis and oxidative phosphorylation and affects the homeostasis of carbohydrate，fat and protein metabolism to induce the chemoresistance of tumor cells. Combination of chemotherapeutic agents with inhibitors specific to different components of glutamine metabolic pathway has obtained favorable clinical results on various tumors. Glutamine metabolic pathway plays a role in drug resistance of tumor cells in various ways. Firstly，the dynamic change of glutamine transporters can directly affect intracellular glutamine content thereby causing drug resistance; secondly，tumor stromal cells including adipocyte，fibroblast and metabolite from tumor microenvironment would give rise to immune-mediated drug resistance; thirdly，the expression and activity of key enzymes in glutamine metabolism also has a critical role in drug resistance of tumors. This article reviews the effects of glutamine metabolic pathway in the development of tumor chemoresistance，in terms of transporters，tumor microenvironment and metabolic enzymes，to provide insight for improving the therapeutic efficacy for drug-resistant tumors.
