Research progress on biomarkers for endometriosis based on lipidomics.
10.3785/j.issn.1008-9292.2020.12.14
- Author:
Cuicui LIN
1
;
Zhengyun CHEN
2
;
Chunyan WANG
1
;
Yongmei XI
1
Author Information
1. Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China.
2. Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
- Publication Type:Journal Article
- Keywords:
Biomarker;
Endometriosis;
Lipidomics;
Review
- MeSH:
Biomarkers/blood*;
Blood Chemical Analysis/trends*;
Body Fluids/chemistry*;
Endometriosis/diagnosis*;
Female;
Humans;
Lipidomics/trends*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(6):779-784
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of endometriosis is not well understood at the moment, and the lack of effective biomarkers often leads to delayed diagnosis of the disease. Lipidomics provides a new approach for the diagnosis and prediction of endometriosis. Sphingomyelin, phosphatidylcholine and phosphatidylserine in peripheral blood, endometrial fluid, peritoneal fluid and follicular fluid have good diagnostic value for endometriosis and disease classification; the lipid metabolites in the eutopic endometrium tissue are expected to be biomarkers of early endometriosis; and the lipid metabolites in peripheral blood are also of great value for predicting endometriosis-related infertility. The development of lipidomics technique will further advance the progress on the pathogenesis, prediction, diagnosis and treatment of endometriosis.
