Expression of tumor-associated vascular insulin receptor in colorectal cancer and its relationship with tumor pathological features.
10.3785/j.issn.1008-9292.2020.12.07
- Author:
Zeran YANG
1
;
Xin ZHANG
1
;
Jie MA
1
;
Li JIN
1
;
Xujun HE
2
Author Information
1. Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
2. Institute of Clinical Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Insulin receptor;
Metabolic syndrome;
Pathology;
Tumor-associated vessel
- MeSH:
Biomarkers, Tumor/genetics*;
Colorectal Neoplasms/physiopathology*;
Gene Expression Regulation, Neoplastic;
Humans;
Neoplasm Staging;
Prognosis;
Receptor, Insulin/genetics*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(6):725-731
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of tumor associated vascular insulin receptor (TVIR) in colorectal cancer with or without metabolic syndrome (MS) and its relationship with the pathological features of colorectal cancer.
METHODS:The expression of TVIR in 220 colorectal cancer specimens was detected by tissue microarray and immunohistochemistry. The relationships between the expression of TVIR and the pathological features (pathological subtypes, histological grade, invasion depth, lymph node metastasis and TNM stage) of colorectal cancer with/without MS were analyzed.
RESULTS:The insulin receptor expression was observed in colorectal cancer tissue or border area between cancer and normal tissue, but not in normal intestinal tissue. The high-expression rates of TVIR in MS group was remarkably lower than that of non-MS group (21.6%vs. 41.0%,
CONCLUSIONS:s: High-expression of TVIR is associated with aggressive pathological features such as invasion, lymph node metastasis and high TNM stage of colorectal cancer, especially for those patients without MS. TVIR could be a useful biological marker for prognosis of colorectal cancer.
