Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion
10.3785/j.issn.1008-9292.2020.12.05
- Author:
Jiayi YE
1
;
Hengpei GONG
1
;
Lingfeng WANG
1
;
Zhen HUANG
1
;
Fengmei QIU
1
;
Xiaoming ZHONG
1
Author Information
1. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Calcium homeostasis;
Cells;
Endoplasmic reticulum stress;
Iridoid glycosides of radix scrophulariae;
Oxygen-glucose deprivation-reperfusion
- MeSH:
Animals;
Cell Survival/drug effects*;
Down-Regulation/drug effects*;
Endoplasmic Reticulum Stress/drug effects*;
Glucose;
In Vitro Techniques;
Iridoid Glycosides/pharmacology*;
Oxygen;
PC12 Cells;
Rats;
Reperfusion;
Reperfusion Injury/prevention & control*;
Snails/chemistry*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(6):705-713
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the regulatory effect of iridoid glycoside of radix scrophulariae (IGRS) on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion
METHODS:Rat pheochromocytoma PC12 cells were pretreated with IGRS (50, 100, 200 μg/mL) for 24h, and the
RESULTS:The damage caused by OGD/R to PC12 cells was significantly reduced by IGRS, with significant effect on increasing survival rate and reducing LDH release (all
CONCLUSIONS:IGRS has neuroprotective effect, which may alleviate cerebral ischemia-reperfusion injury by regulating SERCA2, maintaining calcium balance, and inhibiting endoplasmic reticulum stress-mediated apoptosis.
