Effect of Wubi Shanyao pills on sexual function in mice with kidney-yang-deficiency induced by hydrocortisone.
10.3785/j.issn.1008-9292.2020.12.04
- Author:
Qingqing CHEN
1
;
Chaowen SHAN
1
;
Jie SU
1
;
Wei CHEN
2
;
Jiaming ZHU
2
;
Suhong CHEN
3
;
Guiyuan LYU
1
Author Information
1. College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311400, China.
2. Hangzhou Huqingyutang Pharmaceutical Co. Ltd, Hangzhou 310016, China.
3. Collaborative Innovation Center of Green Pharmaceuticals[JP], Zhejiang University of Technology, Hangzhou 310014, China.
- Publication Type:Journal Article
- Keywords:
Deficiency of kidney yang;
Hydrocortisone;
Mouse;
Sexual function;
Wubi Shanyao pills
- MeSH:
Animals;
Follicle Stimulating Hormone/blood*;
Hydrocortisone;
Hypothalamo-Hypophyseal System;
Kidney/drug effects*;
Kidney Diseases/drug therapy*;
Male;
Mice;
Pituitary-Adrenal System/drug effects*;
Random Allocation;
Sexual Behavior, Animal/drug effects*;
Yang Deficiency/drug therapy*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(6):697-704
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of Chinese medicine Wubi Shanyao pills on sexual function of kidney-yang-deficiency mice induced by hydrocortisone.
METHODS:Male Kunming mice were injected with hydrocortisone for 10 days to prepare the kidney-yang-deficiency model, and administrated with Wubi Shanyao pills (0.91, 1.82, 2.73 g/kg) for 9 weeks. The general behaviors of mice (autonomous activity, grasping power) were observed; sexual behaviors (capture, straddle, ejaculation frequency and incubation period) of mice were detected by mating experiment. The serum levels of cortisol, adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E
RESULTS:Wubi Shanyao pills increased the number of independent activities, grasping power, capture frequency of model mice and shortened the capture latency (all
CONCLUSIONS:Wubi Shanyao pills can improve the sexual function of mice with kidney-yang-deficiency induced by hydrocortisone, which may be related to regulating the hypothalamus-pituitary-adrenal axis (HPA axis), promoting the proliferation of testicular cells, and inhibiting cell apoptosis.
