Research progress on the role of pentraxin 3 in polycystic ovary syndrome.
10.3785/j.issn.1008-9292.2020.08.13
- Author:
Wei WU
1
;
Jian XU
1
Author Information
1. Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
- Publication Type:Journal Article
- Keywords:
Androgen;
Follicular development;
Inflammatory reaction;
Insulin resistance;
Lipid metabolism;
Pentraxin 3;
Polycystic ovary syndrome;
Review
- MeSH:
C-Reactive Protein/metabolism*;
Child;
Female;
Humans;
Insulin Resistance;
Polycystic Ovary Syndrome/physiopathology*;
Serum Amyloid P-Component/metabolism*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(5):637-643
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common endocrine disease of child-bearing period women and one of the main causes of infertility in women. Pentraxin 3 (PTX3) is a multifunctional protein with a series of biological activities. PTX3 participates in the regulation of insulin secretion and glucose metabolism, ovarian cumulus cell function, inflammatory factor activity, androgen metabolism, lipid absorption and transport, and endothelial cell function, thereby improving insulin resistance, promoting follicular development and ovulation, reducing chronic inflammation, inhibiting androgen levels, improving lipid metabolism abnormalities and preventing atherosclerosis and cardiovascular diseases, thus participating in the occurrence of PCOS and its complications. This article reviews the mechanism of PTX3 in PCOS and its complications, trying to provide new ideas and directions for the study of PCOS pathogenesis and its clinical diagnosis and treatment.
