Research progress on macrophage in radiation induced lung injury.
10.3785/j.issn.1008-9292.2020.10.12
- Author:
Mengyao LI
1
;
Pan LIU
1
;
Yuehai KE
1
;
Xue ZHANG
1
Author Information
1. School of Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Review
- Keywords:
Inflammation;
Macrophages;
Pulmonary fibrosis;
Radiation-induced lung injury;
Reactive oxygen species;
Review
- MeSH:
Humans;
Lung/radiation effects*;
Lung Injury/physiopathology*;
Macrophages/metabolism*;
Radiation Injuries;
Radiation Pneumonitis/etiology*;
Radiotherapy/adverse effects*
- From:
Journal of Zhejiang University. Medical sciences
2020;49(5):623-628
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced pulmonary fibrosis (RIPF), is a side effect of radiotherapy for lung cancer and esophageal cancer. Pulmonary macrophages, as a kind of natural immune cells maintaining lung homeostasis, play a key role in the whole pathological process of RILI. In the early stage of RILI, classically activated M1 macrophages secrete proinflammatory cytokines to induce inflammation and produce massive reactive oxygen species (ROS) through ROS-induced cascade to further impair lung tissue. In the later stage of RILI, alternatively activated M2 macrophages secrete profibrotic cytokines to promote the development of RIPF. The roles of macrophage in the pathogenesis of RILI and the related potential clinical applications are summarized in this review.
