Risk factors for metabolic bone disease of prematurity in very/extremely low birth weight infants: a multicenter investigation in China.
- Author:
Xiao-Ri HE
1
;
Can LIANG
;
Yuan-Qiang YU
;
Pei-Jia WU
;
Xiang-Hong CHEN
;
Yu-Jun CHEN
;
Cui-Qing LIU
;
Xiang-Dong OU-YANG
;
Ruo-Bing SHAN
;
Wei-Wei PAN
;
Yan-Mei CHANG
;
Dan WANG
;
Xiao-Yun ZHONG
;
Kai-Ju LUO
1
;
Yong-Hui YANG
1
;
Qing-Yi DONG
1
;
Jin-Tao HU
1
;
Ming-Feng HE
1
;
Xiao-Mei TONG
;
Ping-Yang CHEN
1
Author Information
1. Laboratory of Neonatal Disease, Institute of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Multicenter Study
- MeSH:
Birth Weight;
Bone Diseases, Metabolic/etiology*;
China/epidemiology*;
Female;
Humans;
Infant;
Infant, Extremely Low Birth Weight;
Infant, Newborn;
Infant, Premature;
Infant, Very Low Birth Weight;
Pregnancy;
Retrospective Studies;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(6):555-562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the incidence rate and risk factors for metabolic bone disease of prematurity (MBDP) in very low birth weight/extremely low birth weight (VLBW/ELBW) infants.
METHODS:The medical data of 61 786 neonates from multiple centers of China between September 1, 2013 and August 31, 2016 were retrospectively investigated, including 504 VLBW/ELBW preterm infants who met the inclusion criteria. Among the 504 infants, 108 infants diagnosed with MBDP were enrolled as the MBDP group and the remaining 396 infants were enrolled as the non-MBDP group. The two groups were compared in terms of general information of mothers and preterm infants, major diseases during hospitalization, nutritional support strategies, and other treatment conditions. The multivariate logistic regression analysis was used to investigate the risk factors for MBDP.
RESULTS:The incidence rate of MBDP was 19.4% (88/452) in VLBW preterm infants and 38.5% (20/52) in ELBW preterm infants. The incidence rate of MBDP was 21.7% in preterm infants with a gestational age of < 32 weeks and 45.5% in those with a gestational age of < 28 weeks. The univariate analysis showed that compared with the non-MBDP group, the MBDP group had significantly lower gestational age and birth weight, a significantly longer length of hospital stay, and a significantly higher incidence rate of extrauterine growth retardation (
CONCLUSIONS:A lower gestational age, hypocalcemia, extrauterine growth retardation at discharge, and neonatal sepsis may be associated an increased risk of MBDP in VLBW/ELBW preterm infants. It is necessary to strengthen perinatal healthcare, avoid premature delivery, improve the awareness of the prevention and treatment of MBDP among neonatal pediatricians, and adopt positive and reasonable nutrition strategies and comprehensive management measures for preterm infants.
