Association between maternal reduced folate carrier gene polymorphisms and congenital heart disease in offspring: a case-control study.
- Author:
Jia-Bi QIN
1
;
Xiao-Qi SHENG
;
Ting-Ting WANG
;
Peng HUANG
;
Yi-Huan LI
;
Liu LUO
;
Yi-Ping LIU
;
Jing-Yi DIAO
;
Ping ZHU
1
Author Information
1. Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510100, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Child;
Female;
Genetic Predisposition to Disease;
Genotype;
Heart Defects, Congenital/genetics*;
Humans;
Infant;
Polymorphism, Single Nucleotide;
Reduced Folate Carrier Protein/genetics*;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(6):547-554
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the association between maternal reduced folate carrier (
METHODS:A hospital-based case-control study was conducted. The mothers of 683 infants with CHD who attended the Department of Cardiothoracic Surgery, Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group. The mothers of 740 healthy infants without any deformity who attended the hospital during the same period of time were enrolled as the control group. A questionnaire survey was performed to collect the exposure data of subjects. Venous blood samples of 5 mL were collected from the mothers for genetic polymorphism detection. A multivariate logistic regression analysis was used to evaluate the association of
RESULTS:After control for confounding factors, the multivariate logistic regression analysis showed that maternal
CONCLUSIONS:Maternal
