Research advances in the role of ferroptosis in neonatal hypoxic-ischemic brain damage.
- Author:
Kai-Yi ZHU
1
;
Ming-Yan HEI
1
Author Information
1. Neonatal Center, Beijing Children's Hospital, Capital Medical University/National Center for Child Health, Beijing 100045, China.
- Publication Type:Review
- MeSH:
Animals;
Animals, Newborn;
Brain;
Child;
Child, Preschool;
Ferroptosis;
Humans;
Hypoxia-Ischemia, Brain;
Infant, Newborn;
Neurons
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(5):536-541
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic brain damage (HIBD) remains an important cause of neonatal death and disability in infants and young children, but it has a complex mechanism and lacks specific treatment methods. As a new type of programmed cell death, ferroptosis has gradually attracted more and more attention as a new therapeutic target. This article reviews the research advances in abnormal iron metabolism, glutamate antiporter dysfunction, and abnormal lipid peroxide regulation which are closely associated with ferroptosis and HIBD.
