Risk factors for neonatal congenital hypothyroidism: a Meta analysis.
- Author:
Ji ZHANG
1
;
Yang LI
1
Author Information
1. Institute of Endemic Disease, Guizhou Provincial Center for Disease Prevention and Control, Guiyang 550004, China.
- Publication Type:Meta-Analysis
- MeSH:
China;
Congenital Hypothyroidism/etiology*;
Cross-Sectional Studies;
Female;
Humans;
Infant, Newborn;
Pregnancy;
Premature Birth;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(5):505-512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the risk factors for congenital hypothyroidism (CH) in neonates, and to provide a reference for the prevention of CH.
METHODS:The databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, SpringerLink, and Elsevier/ScienceDirect were searched for studies on the risk factors for CH in neonates published up to August 1, 2020. R 3.6.2 and RevMan 5.3 software were used to perform a Meta analysis.
RESULTS:A total of 20 studies were included, with 13 case-control studies and 7 cross-sectional studies. There were 11 564 neonates in total, with 3 579 neonates in the case group and 7 985 neonates in the control group. The Meta analysis showed that advanced maternal age (
CONCLUSIONS:Advanced maternal age, gestational thyroid disease, gestational diabetes mellitus, anxiety, medication during pregnancy, radiation exposure during pregnancy, family history of thyroid disease, low birth weight, fetal macrosomia, preterm birth, post-term birth, twin pregnancy or multiple pregnancy, and birth defects may increase the risk of CH in neonates.