Association between serum trace elements and core symptoms in children with autism spectrum disorder: a national multicenter survey.
- Author:
Xin-Hui ZHANG
1
;
Ting YANG
1
;
Jie CHEN
1
;
Li CHEN
1
;
Ying DAI
1
;
Fei-Yong JIA
;
Li-Jie WU
;
Yan HAO
;
Ling LI
;
Jie ZHANG
;
Xiao-Yan KE
;
Ming-Ji YI
;
Qi HONG
;
Jin-Jin CHEN
;
Shuan-Feng FANG
;
Yi-Chao WANG
;
Qi WANG
;
Chun-Hua JIN
;
Ting-Yu LI
1
Author Information
- Publication Type:Multicenter Study
- MeSH: Autism Spectrum Disorder; Child; China; Copper/analysis*; Humans; Trace Elements/analysis*; Zinc
- From: Chinese Journal of Contemporary Pediatrics 2021;23(5):445-450
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the association of serum levels of trace elements with core symptoms in children with autism spectrum disorder (ASD).
METHODS:From September 2018 to September 2019, an investigation was performed for 1 020 children with ASD and 1 038 healthy children matched for age and sex in the outpatient service of grade A tertiary hospitals and special education institutions in 13 cities of China. Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood Autism Rating Scale (CARS) were used to assess the core symptoms of the children with ASD. The inductively coupled plasma mass spectrometry was used to measure serum levels of trace elements magnesium, iron, copper, and zinc.
RESULTS:The children with ASD had significantly lower serum levels of magnesium, copper, and zinc than the healthy children (
CONCLUSIONS:The serum levels of magnesium and zinc may be associated with core symptoms in children with ASD, which requires further studies. The nutritional status of trace elements should be monitored for children with ASD in clinical practice.
