Protective effect of transplantation of human oligodendrocyte precursor cells in a rat model of white matter injury.
- Author:
Xin ZHONG
1
;
Zuo LUAN
;
Jing ZANG
;
Qian GUAN
;
Yin-Xiang YANG
;
Qian WANG
;
Yuan SHI
1
Author Information
1. Department of Neonatology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing 400014, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Newborn;
Humans;
Myelin Sheath;
Oligodendrocyte Precursor Cells;
Oligodendroglia;
Rats;
White Matter
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(4):410-415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of human oligodendrocyte precursor cell (hOPC) transplantation in the treatment of white matter injury (WMI).
METHODS:Neonatal rats were randomly divided into a sham-operation group, a model group, and a transplantation group (
RESULTS:The place navigation test using the Morris water maze showed that the model group had a significantly longer escape latency than the sham-operation group, and compared with the model group, the transplantation group had a significant reduction in escape latency (
CONCLUSIONS:Intrathecal hOPC transplantation may alleviate neurological injury and promote remyelination in a rat model of WMI.
