Reduced Cortical Thickness in the Temporal Pole, Insula, and Pars Triangularis in Patients with Panic Disorder.
10.3349/ymj.2017.58.5.1018
- Author:
Eun Kyoung KANG
1
;
Kang Soo LEE
;
Sang Hyuk LEE
Author Information
1. Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Korea. leesanghyuk@yahoo.com
- Publication Type:Original Article
- Keywords:
Panic disorder;
cortical thickness;
temporal pole;
insula;
pars triangularis
- MeSH:
Anxiety;
Broca Area*;
Depression;
Humans;
Neuroimaging;
Panic Disorder*;
Panic*
- From:Yonsei Medical Journal
2017;58(5):1018-1024
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Recent neuroimaging findings have revealed that paralimbic and prefrontal regions are involved in panic disorder (PD). However, no imaging studies have compared differences in cortical thickness between patients with PD and healthy control (HC) subjects. MATERIALS AND METHODS: Forty-seven right-handed patients with PD who met the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders-4th edition-text revision, and 30 HC subjects were enrolled. We used the FreeSurfer software package for estimating the cortical thickness of regions of interest, including the temporal pole, insula, and pars triangularis (mid-ventrolateral prefrontal cortex). RESULTS: Cortical thickness of the temporal pole (p=0.033, right), insula (p=0.017, left), and pars triangularis (p=0.008, left; p=0.025, right) in patients with PD was significantly lower, compared with HC subjects (Benjamini-Hochberg false discovery rate correction). Exploratory analysis revealed a significant negative correlation between the cortical thickness of the right temporal pole and Beck Depression Inventory scores (r=-0.333, p=0.027) in patients with PD and positive correlations between the cortical thickness of the left pars triangularis and Panic Disorder Severity Scale (r=0.429, p=0.004), Anxiety Sensitivity Index-Revised (r=0.380, p=0.011), and Beck Anxiety Inventory (r=0.421, p=0.004) scores using Pearson's correlation. CONCLUSION: Ours study is the first to demonstrate cortical thickness reduction in the temporal pole, insula, and pars triangularis in patients with PD, compared with the HC subjects. These findings suggest that reduced cortical thickness could play an important role in the pathophysiology of PD.
