A review on the genetic mechanism of chromatin remodeling in children with neurodevelopmental disorders.
- Author:
Fang-Bing CHEN
1
;
Wen-Hao ZHOU
1
Author Information
1. Department of Neonatology, Children's Hospital, Fudan University, Shanghai 201102, China.
- Publication Type:Review
- MeSH:
Child;
Chromatin;
Chromatin Assembly and Disassembly;
Humans;
Neurodevelopmental Disorders/genetics*;
Neurogenesis;
Transcription Factors/genetics*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(3):315-318
- CountryChina
- Language:Chinese
-
Abstract:
Neural development is regulated by both external environment and internal signals, and in addition to transcription factors, epigenetic modifications also play an important role. By focusing on the genetic mechanism of ATP-dependent chromatin remodeling in children with neurodevelopmental disorders, this article elaborates on the effect of four chromatin remodeling complexes on neurogenesis and the development and maturation of neurons and neuroglial cells and introduces the clinical research advances in neurodevelopmental disorders.
