Association between serum uric acid and subclinical cardiac damage in children with primary hypertension.
- Author:
Miao HOU
1
;
Ling SUN
1
;
Wan-Ping ZHOU
1
;
Yue-Yue DING
1
;
Qiu-Qin XU
1
;
Lei CAO
1
;
Jie SHEN
1
;
Dao-Ping YANG
1
;
Hai-Tao LYU
1
Author Information
1. Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, China.
- Publication Type:Journal Article
- MeSH:
Blood Pressure;
Child;
Humans;
Hypertension/complications*;
Hypertrophy, Left Ventricular/etiology*;
Retrospective Studies;
Uric Acid
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(2):174-179
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the condition of subclinical cardiac damage in children with primary hypertension and the association between serum uric acid and subclinical cardiac damage.
METHODS:A retrospective analysis was performed on the medical data of 55 children who were hospitalized and diagnosed with primary hypertension in the Department of Cardiology, Children's Hospital of Soochow University from January 2015 to June 2020. Forty-five healthy children, matched for age and sex, were enrolled as the control group. The two groups were compared in terms of clinical features, laboratory examination, and parameters for left ventricular structure, systolic function, and diastolic function. The correlation of serum uric acid with the parameters for left ventricular structure, systolic function, and diastolic function in children with primary hypertension was analyzed.
RESULTS:Compared with the control group, the hypertension group had significantly higher left ventricular mass (LVM), left ventricular mass index (LVMI), and relative wall thickness (RWT) (
CONCLUSIONS:Children with primary hypertension may have subclinical cardiac damage such as left ventricular hypertrophy, left ventricular diastolic dysfunction, left atrial enlargement, and proximal aortic dilation. Elevated serum uric acid is significantly associated with cardiac damage in children with primary hypertension.
