Clinical features of sleep-disordered breathing in children with neuromuscular disease.
- Author:
Qin YANG
1
;
Yan-Min BAO
1
;
Xin-Guo LU
;
Guo-Jun YUN
;
Ai-Liang LIU
1
;
Yue-Jie ZHENG
1
;
Fei-Qiu WEN
1
Author Information
1. Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Neuromuscular Diseases/complications*;
Polysomnography;
Retrospective Studies;
Sleep;
Sleep Apnea Syndromes/etiology*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(2):158-163
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical features of sleep-disordered breathing (SDB) in children with neuromuscular disease (NMD).
METHODS:A retrospective analysis was performed on the medical data of 18 children who were diagnosed with NMD and underwent polysomnography (PSG) (NMD group). Eleven children without NMD who had abnormal sleeping habit and normal sleep structure on PSG were enrolled as the control group. The two groups were compared in terms of the daily and nocturnal symptoms of SDB, incidence rate of obstructive sleep apnea (OSA), pulmonary function, end-tidal partial pressure of carbon dioxide (PetCO
RESULTS:In the NMD group, 16 children (89%) had related daily and nocturnal symptoms of SDB, and the youngest age was 1 year at the onset of such symptoms. Compared with the control group, the NMD group had significant reductions in total sleep time and sleep efficiency (
CONCLUSIONS:There is a high proportion of children with SDB among the children with NMD, and SDB can be observed in the early stage of NMD, which results in the damage of sleep structure and the reduction in sleep efficiency. Respiratory events are mainly obstructive events, and oxygen reduction events are mainly observed during REM sleep.
