Clinical features of children with Guillain-Barré syndrome and the significance of Brighton criteria.
- Author:
Ju-Fang LIANG
1
;
Rui-Di SUN
1
;
Rui-Xue WANG
;
Jun LUO
;
Heng-Dong WANG
;
Jun JIANG
1
Author Information
1. Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China.
- Publication Type:Journal Article
- MeSH:
Child;
Child, Preschool;
Extremities;
Guillain-Barre Syndrome/diagnosis*;
Humans;
Muscle Weakness;
Physical Examination;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical features of children with Guillain-Barré syndrome (GBS) and the significance of Brighton criteria in childhood GBS.
METHODS:A retrospective analysis was performed on the medical data of 72 children with GBS. Brighton criteria were used for the grading of diagnostic certainty (level 1 as the highest level, and level 4 as the lowest level). A Spearman's rank correlation analysis was used to evaluate the correlation of auxiliary examinations with the level of diagnostic certainty of Brighton criteria.
RESULTS:A total of 72 children with GBS were enrolled, with a mean age of onset of (98±32) months. All children (100%, 72/72) had weakness of bilateral limbs and disappearance or reduction of tendon reflex, and limb weakness reached the highest level of severity within 4 weeks. Of all the 72 children, 68 (94%) had positive results of neural electrophysiological examination and 51 (71%) had positive results of cerebrospinal fluid (CSF) examination, and the positive rate of neural electrophysiological examination was significantly higher than that of CSF examination (
CONCLUSIONS:Most of the children with GBS meet Brighton criteria level 1, and the positive results of CSF examination and neural electrophysiological examination play an important role in improving the level of diagnostic certainty of Brighton criteria. Neural electrophysiological examination has a higher positive rate than CSF examination in the early stage of the disease.
