Effect of pertussis vaccination on clinical manifestations of infants and young children with pertussis.
- Author:
Qi-Qin TANG
1
;
Chuan GAN
1
;
Xiao-Ying WU
1
;
Hong-Mei XU
1
;
Zhen-Zhen ZHANG
1
Author Information
1. Department of Infection, Children's Hospital, Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders(Chongqing)/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
- Publication Type:Journal Article
- MeSH:
Child;
Child, Preschool;
Humans;
Incidence;
Infant;
Pneumonia;
Retrospective Studies;
Vaccination;
Whooping Cough/prevention & control*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(2):138-142
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of pertussis vaccination on the clinical manifestations of infants and young children with pertussis.
METHODS:A retrospective analysis was performed to investigate the differences in clinical manifestations and peripheral blood cell levels between pertussis children with different pertussis vaccination status.
RESULTS:A total of 1 083 children with pertussisat at age of < 3 years were enrolled, with 551 children in the unvaccinated group and 532 in the vaccinated group. Of all the children, 392 had an age of onset of < 3 months (372 were unvaccinated and 20 were vaccinated) and 691 children had an age of onset of ≥ 3 months (179 were unvaccinated and 512 were vaccinated). Compared with the vaccinated group, the unvaccinated group had a longer length of hospital stay and a higher incidence rate of respiratory failure (
CONCLUSIONS:Pertussis vaccination can reduce the incidence of severe pneumonia and respiratory failure and alleviate the severity of respiratory complications in infants and young children with pertussis.
