Effect and mechanism of vascular endothelial growth factor-A on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension.
- Author:
Jing CAO
1
;
Jia-Yuan LUO
1
;
Dian WU
;
Qian ZHAO
;
Ming-Xia LI
1
Author Information
1. Department of Neonatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Newborn;
Hypertension, Pulmonary/etiology*;
Hypoxia;
Pulmonary Artery;
Rats;
Rats, Wistar;
Vascular Endothelial Growth Factor A;
Vascular Remodeling
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(1):103-110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the role of vascular endothelial growth factor-A (VEGF-A) in pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension (HPH) by regulating survivin (SVV).
METHODS:A total of 96 neonatal rats were randomly divided into three groups: HPH+VEGF-A group, HPH group, and control group. Each group was further randomly divided into 3-, 7-, 10-, and 14-day subgroups (
RESULTS:The HPH group had a significantly higher mean RVSP than the control and HPH+VEGF-A groups at each time point (
CONCLUSIONS:Prophylactic intratracheal administration of exogenous VEGF-A in neonatal rats with HPH can inhibit pulmonary vascular remodeling and reduce pulmonary arterial pressure by upregulating the expression of SVV in the early stage of hypoxia. This provides a basis for the interventional treatment of pulmonary vascular remodeling in neonatal HPH.
