Clinical effect and mechanism of total glucosides of paeony in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis: a prospective randomized controlled study.
- Author:
Kuan-Furong SHAO
1
;
Feng-Jun GUAN
1
;
Chen DONG
1
Author Information
1. Department of Pediatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.
- Publication Type:Journal Article
- MeSH:
Child;
Glucosides/therapeutic use*;
Humans;
Nephritis;
Paeonia;
Prospective Studies;
Purpura, Schoenlein-Henoch/drug therapy*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(1):49-54
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).
METHODS:Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (
RESULTS:Compared with the healthy children before treatment, the children with HSPN had higher proportion of Tfh cells and expression levels of IL-21 and IL-4 (
CONCLUSIONS:TGP has a marked clinical effect in the treatment of HSPN and can reduce the inflammatory response of the kidney and exert a protective effect on the kidney by inhibiting the proliferation of Tfh cells and downregulating the expression of IL-21 and IL-4 in plasma.
