Safety of two ventilator weaning strategies after high-frequency oscillatory ventilation in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial.
- Author:
Ming-Yuan HE
1
;
Yu-Cong LIN
1
;
Lin-Lin WU
1
;
Wei SHEN
1
;
Li-Xia TANG
1
;
Yao ZHU
1
;
Jing HUANG
1
;
Xin-Zhu LIN
1
Author Information
1. Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, Fujian 361001, China.
- Publication Type:Randomized Controlled Trial
- MeSH:
High-Frequency Ventilation;
Humans;
Infant, Newborn;
Infant, Premature;
Prospective Studies;
Respiration, Artificial;
Respiratory Distress Syndrome, Newborn/therapy*;
Ventilator Weaning
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(1):18-24
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the safety of two ventilator weaning strategies after high-frequency oscillatory ventilation (HFOV) for the treatment of neonatal respiratory distress syndrome (NRDS) in preterm infants.
METHODS:A prospective randomized controlled trial was conducted for 101 preterm infants with NRDS, with a gestational age of ≤32
RESULTS:There was no significant difference in the failure rate of ventilator weaning within 72 hours (8% vs 14%,
CONCLUSIONS:For preterm infants with NRDS, the strategy of weaning directly from HFOV is safe and reliable and can reduce the duration of invasive mechanical ventilation, and therefore, it holds promise for clinical application.
