Clinical features of children with recurrent Kawasaki disease: a Meta analysis.
- Author:
Gang LUO
1
;
Si-Lin PAN
1
;
Si-Bao WANG
1
;
Zhan-Hui DU
1
;
Zhi-Xian JI
1
Author Information
1. Heart Center, Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, China.
- Publication Type:Meta-Analysis
- MeSH:
Child;
Chronic Disease;
Coronary Vessels/pathology*;
Edema/etiology*;
Female;
Fever/etiology*;
Humans;
Male;
Mucocutaneous Lymph Node Syndrome/physiopathology*;
Recurrence
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(12):1306-1312
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical features of children with recurrent Kawasaki disease (KD).
METHODS:PubMed, Web of Science, Embase, CNKI, Wanfang Med Online, and Weipu Data were searched for case-control studies on the clinical features of initial and recurrent KD. The articles were screened according to the inclusion and exclusion criteria. RevMan 5.3 software was used to perform the Meta analysis. Effect models were selected based on the results of heterogeneity test, and then pooled
RESULTS:A total of 9 case-control studies were included, with 12 059 children with KD in total, among whom 206 children had recurrent KD (127 boys/61.7%; 79 girls/38.3%). The results of the Meta analysis showed that compared with the initial KD onset, the children with recurrent KD had a shorter duration of fever (
CONCLUSIONS:Current evidence shows that children with recurrent KD tend to have a shorter duration of fever and a lower incidence of swelling of the hands and feet. KD recurrence is more common in boys. Current evidence does not show an increased risk of developing coronary artery lesions in children with recurrent KD.
