Therapeutic effects of different drug regimens and metabolic markers in children with bipolar affective disorder: a comparative analysis.
- Author:
Bin LI
1
;
Yan-Jie QI
1
;
Yun CHEN
1
;
Zhi-Xia ZHANG
1
;
Fan HE
1
;
Yi ZHENG
1
Author Information
1. Department of Pediatric Psychiatry, Beijing Anding Hospital, Capital Medical University/National Clinical Research Center for Psychological and Mental Disorders/Beijing Key Laboratory for Diagnosis and Treatment of Mental Disorders, Beijing 100088, China.
- Publication Type:Journal Article
- MeSH:
Antipsychotic Agents/therapeutic use*;
Biomarkers/blood*;
Bipolar Disorder/drug therapy*;
Child;
Cholesterol, HDL;
Humans;
Mood Disorders;
Retrospective Studies;
Triglycerides
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(12):1295-1299
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the changes in metabolic markers and clinical outcome after treatment with different drug regimens in children with bipolar affective disorder.
METHODS:A retrospective analysis was performed on the medical data of 220 children with bipolar affective disorder who attended the hospital from January 2017 to January 2020. According to the treatment method, 112 children treated with atypical antipsychotic drugs alone were enrolled as the control group, and 108 children treated with atypical antipsychotic drugs combined with mood stabilizer were enrolled as the study group. The two groups were compared in terms of baseline data, changes in related metabolic markers[fasting insulin (FIN), glycosylated hemoglobin (HbAlc), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] after treatment, incidence rate of metabolic syndrome, and clinical outcome.
RESULTS:There were no significant differences in the baseline data including age, sex, and course of disease between the two groups (
CONCLUSIONS:Atypical antipsychotic drugs combined with mood stabilizer in the treatment of bipolar disorder in children have little effect on the level of metabolic markers, and the curative effect is significant.
