Clinical characteristics and prognostic analysis of pediatric pro-B cell acute lymphoblastic leukemia.
- Author:
Yu-Juan XUE
1
;
Ai-Dong LU
1
;
Yu WANG
1
;
Yue-Ping JIA
1
;
Ying-Xi ZUO
1
;
Le-Ping ZHANG
1
Author Information
1. Department of Pediatrics, People's Hospital, Peking University, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Antigens, CD/genetics*;
Child;
Child, Preschool;
Disease-Free Survival;
Female;
Histone-Lysine N-Methyltransferase/genetics*;
Humans;
Infant;
Male;
Myeloid-Lymphoid Leukemia Protein/genetics*;
Neoplasm, Residual/diagnosis*;
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics*;
Prognosis;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(12):1286-1294
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical-biological characteristics and prognosis of pediatric pro-B cell acute lymphoblastic leukemia (pro-B-ALL).
METHODS:A total of 64 patients aged less than 18 years old with pro-BALL were enrolled. Clinical characteristics, therapeutic effect and prognostic factors were retrospectively analyzed.
RESULTS:Pro-B-ALL occurred in 6.23% (64/1 028) of pediatric ALL. Among the 64 patients, 35 were male and 29 were female. The median age was 7.0 years (range 0.4-16.0 years) at diagnosis, of which 39% and 6% were ≥ 10 years old and < 1 year old respectively. The median WBC count was 25.5×10
CONCLUSIONS:Pediatric pro-B ALL is a heterogeneous disease with clinical and biological diversity. Biological characteristics, such as immunological markers, genetic alterations, and MRD at 3 months after chemotherapy may be important factors for the long-term prognosis.
