Clinical features of neuroblastoma: an analysis of 44 children.
- Author:
Cheng-Guang ZHU
1
;
Xiang-Ling HE
;
Zhi-Ge TANG
;
Ke-Ke CHEN
;
Run-Ying ZOU
;
Xin TIAN
;
Ya-Lan YOU
Author Information
1. Department of Pediatric Hematology and Oncology, Hunan Provincial People's Hospital, Changsha 410005, China. hexiangl@hunnu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Infant;
Infant, Newborn;
Neoplasm Recurrence, Local;
Neoplasm Staging;
Neuroblastoma;
Phosphopyruvate Hydratase;
Retrospective Studies;
Survival Rate
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(11):1193-1197
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical features of neuroblastoma (NB) and the factors influencing survival rate.
METHODS:A total of 44 children with NB who were admitted from April 2016 to February 2020 were enrolled as research subjects. A retrospective analysis was performed on their medical data and follow-up data.
RESULTS:The common clinical symptoms of these 44 children were fever (10/44, 23%), mass (9/44, 20%), abdominal pain (8/44, 18%), cough (7/44, 16%), pale complexion (3/44, 7%), claudication (2/44, 5%), and abnormal activity (2/44, 5%). According to the INSS stage, 2 children (4%) had stage I NB, 5 children (11%) had stage II NB, 5 children (11%) had stage III NB, and 32 children (73%) had stage IV NB. The mean follow-up time was (15.3±1.5) months, with a recurrence rate of 20% and an overall survival rate of 82%. Among the 44 children, 29 (66%) achieved event-free survival and 7 (16%) had survival with tumor. The univariate analysis showed that a pathological type of NB and an increase in serum neuron-specific enolase (NSE) decreased the overall survival rate of children with NB (P<0.05).
CONCLUSIONS:The clinical symptoms of children with NB are not specific at the first visit. Fever, abdominal pain, and mass are common symptoms, and there is a high proportion of children in the advanced stage. The pathological type of NB and an increase in serum NSE may be associated with a reduction in the overall survival rate of children with NB.
