Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice.
- Author:
Fathiah ABDULLAH
1
;
Mohamed Noor KHAN NOR-ASHIKIN
1
;
Renu AGARWAL
2
;
Yuhaniza Shafinie KAMSANI
1
;
Mastura ABD MALEK
1
;
Nor Salmah BAKAR
3
;
Aqila-Akmal MOHAMMAD KAMAL
1
;
Mimi-Sophia SARBANDI
1
;
Nor-Shahida ABDUL RAHMAN
1
;
Nurul Huda MUSA
4
Author Information
- Publication Type:Research Support, Non-U.S. Gov't
- Keywords: diabetes mellitus; glutathione; mice; sperm quality; testis histology
- From: Asian Journal of Andrology 2021;23(3):281-287
- CountryChina
- Language:English
- Abstract: Diabetes mellitus (DM) is known to cause reproductive impairment. In men, it has been linked to altered sperm quality and testicular damage. Oxidative stress (OS) plays a pivotal role in the development of DM complications. Glutathione (GSH) is a part of a nonenzymatic antioxidant defense system that protects lipid, protein, and nucleic acids from oxidative damage. However, the protective effects of exogenous GSH on the male reproductive system have not been comprehensively examined. This study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac mice. GSH at the doses of 15 mg kg
