The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
- Author:
Xiao-Feng YUE
1
;
Chong-Xing SHEN
1
;
Jian-Wu WANG
1
;
Lin-Yong DAI
1
;
Qiang FANG
1
;
Lei LONG
2
;
Yi ZHI
1
;
Xue-Ru LI
3
;
Ya-Wei WANG
2
;
Gu-Fang SHEN
2
;
Zu-Juan LIU
2
;
Chun-Meng SHI
2
;
Wei-Bing LI
1
Author Information
- Publication Type:Research Support, Non-U.S. Gov't
- Keywords: IR-61; corpus cavernosum smooth muscle cells; diabetes; erectile dysfunction; mitochondria
- From: Asian Journal of Andrology 2021;23(3):249-258
- CountryChina
- Language:English
- Abstract: This study aimed to evaluate the therapeutic effect of IR-61, a novel mitochondrial heptamethine cyanine dye with antioxidant effects, on diabetes mellitus-induced erectile dysfunction (DMED). Eight-week-old male Sprague-Dawley rats were intraperitoneally injected with streptozotocin (STZ) to induce type 1 diabetes. Eight weeks after STZ injection, all rats were divided into three groups: the control group, DM group, and DM + IR-61 group. In the DM + IR-61 group, the rats were administered IR-61 (1.6 mg kg
