Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains.

Author: Junaid KASHIR ¹ ; Bhavesh V MISTRY ² ; Maha Adel GUMSSANI ¹ ; Muhammad RAJAB ² ; Reema ABU-DAWAS ¹ ; Falah ALMOHANNA ² ; Michail NOMIKOS ³ ; Celine JONES ⁴ ; Raed ABU-DAWUD ² ; Nadya AL-YACOUB ² ; Kevin COWARD ⁴ ; F Anthony LAI ³ ; Abdullah M ASSIRI ¹
Author Information

1. College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
2. Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
3. College of Medicine, QU Health, Qatar University, Doha PO Box 2713, Qatar.
4. Nuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.
Publication Type:Research Support, Non-U.S. Gov't
Keywords: ageing; fertilization; male infertility; oocyte activation; phospholipase C zeta; sperm
From: Asian Journal of Andrology 2021;23(2):178-187
CountryChina
Language:English
Abstract: Sperm-specific phospholipase C zeta (PLCζ) initiates intracellular calcium (Ca