Intracerebroventricular drug administration.
10.12793/tcp.2017.25.3.117
- Author:
Arthur J. ATKINSON
1
Author Information
1. Department of Pharmacology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA. art_atkinson@msn.com
- Publication Type:Review
- Keywords:
Intracerebroventricular drug administration;
Cerebrospinal fluid physiology;
Pharmacokinetics;
Meningitis;
CNS cancer
- MeSH:
Blood-Brain Barrier;
Central Nervous System;
Humans;
Meningitis;
Pharmacokinetics
- From:Translational and Clinical Pharmacology
2017;25(3):117-124
- CountryRepublic of Korea
- Language:English
-
Abstract:
Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily. As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations to treat patients with CNS infectious and neoplastic diseases. This route of drug administration also has the advantage of minimizing systemic toxicity.
