Progress in genetic research on tooth agenesis associated with Wnt/beta-catenin signaling pathway.
10.3760/cma.j.cn511374-20200403-00238
- Author:
Xiujuan ZHU
1
;
Yaping SHEN
;
Jing ZHENG
Author Information
1. Department of Stomatology, Zhejiang Lvcheng Cardiovascular Hospital, Hangzhou, Zhejiang 310012, China. candy88zj@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Anodontia/genetics*;
Genetic Research;
Humans;
Tooth;
Wnt Proteins/genetics*;
Wnt Signaling Pathway/genetics*
- From:
Chinese Journal of Medical Genetics
2021;38(5):506-509
- CountryChina
- Language:Chinese
-
Abstract:
Tooth agenesis is the most common form of congenital craniofacial dysplasia seen in stomatology clinics, which may be caused by genetic and/or environmental factors. Tooth development is regulated by a series of signaling pathways, and variants in any of these strictly balanced signaling cascades can result in tooth agenesis and/or other oral defects. Notably, variants of genes of the Wnt/beta-catenin signaling pathway are important cause for both non-syndromic and syndromic tooth agenesis. This article has provided a review for the molecular genetics of tooth agenesis associated with Wnt/beta-catenin signaling pathway, which may shed lights on the etiology and molecular mechanism of this disease.
