Advances in research on the development of female germ cells.
10.3760/cma.j.cn511374-20200226-00102
- Author:
Xiaojie SUN
1
;
Congrong LIU
;
Yan LIU
Author Information
1. Department of Pathology, School of Basic Medical Sciences, the Third Hospital of Peking University Health Science Center, Beijing 100191, China. laylaly@126.com.
- Publication Type:Journal Article
- MeSH:
Female;
Germ Cells;
Humans;
Meiosis;
Oocytes;
Oogenesis/genetics*;
Signal Transduction
- From:
Chinese Journal of Medical Genetics
2021;38(3):286-289
- CountryChina
- Language:Chinese
-
Abstract:
The development of female germ cells can be mainly divided into two stages: fetal germ cells and oocytes in folliculogenesis after puberty. Mitosis-meiosis transition, meiosis arrest and re-activation are the key phases of the development. Several phases may be characterized by their distinct molecular events, which involve precise regulation of gene expression and interaction with corresponding gonadal niche cells. In recent years, single-cell transcriptome studies have clarified phase-specific patterns of gene expression, signaling pathways and epigenetic modification during oogenesis and folliculogenesis. These works have provided important insights into the development of female germ cells and pathogenesis of germ-cell related diseases, which may promote clinical application of reproductive genetic research.
