Predictors of Axillary Lymph Node Metastases in Patients with T1 Breast Cancer.
- Author:
Kwang Nam LEE
1
;
Je Ryong KIM
;
Eil Sung CHANG
Author Information
1. Department of Surgery, College of Medicine, Chungnam National University, Taejon, Korea.
- Publication Type:Original Article
- Keywords:
Axillary lymph node metastases;
Breast cancer;
Predictive factors
- MeSH:
Breast Neoplasms*;
Breast*;
Drug Therapy;
Estrogens;
Humans;
Incidence;
Lymph Nodes*;
Neoplasm Metastasis*;
Receptors, Progesterone;
Risk Assessment
- From:Journal of the Korean Surgical Society
2000;59(5):577-583
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In T1 tumors, the reported incidence of lymph node metastasis ranges from 6% to 31%. The authors analyzed the clinical and the pathological parameters of T1 tumors for their association with the likelihood of axillary lymph node metastases (ALNM). METHODS: The authors reviewed data from 57 patients with T1 breast carcinomas who had undergone a level I/II axillary dissection from January 1996 to March 2000. The association between the incidence of ALNM and clinical/pathologic factors (age, site, size, neoadjuvant chemotherapy, histologic grade, lymphovascular invasion, estrogen receptor status, progesterone receptor status, p53, and c-erbB-2) were analyzed by using chi-square tests. RESULTS: Approximately 42% of the 57 patients with a T1 breast carcinoma had ALNM. Chi-square tests showed that lymph node metastases were associated with tumor size (P=0.043), lymphovascular invasion (P=0.001), and expression of c-erbB-2 (P=0.026). CONCLUSION: The authors conclude that the charac teristics of the primary tumor can be used to estimate the risk of ALNM in patients with a T1 breast carcinoma. Such a risk assessment might facillitate appropriate management.
