Effects of manual loading on calcitonin gene-related peptide and nerve growth factor in rats with chronic low back pain.
10.12200/j.issn.1003-0034.2021.03.018
- Author:
Zhi-Zhen LYU
1
;
Qing-Guang ZHU
1
;
Ling-Jun KONG
1
;
Yan-Bin CHENG
1
;
Guang-Xin GUO
1
;
Xin ZHOU
1
;
Shuai-Pan ZHANG
1
;
Min FANG
1
Author Information
1. Yueyang Hospital of Integrated Trditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
- Publication Type:Journal Article
- Keywords:
Calcitonin gene-related peptide;
Chronic low back pain;
Inflammatory microenvironment;
Manipulation;
Nerve growth factor
- MeSH:
Animals;
Calcitonin;
Calcitonin Gene-Related Peptide;
Low Back Pain/therapy*;
Male;
Nerve Growth Factor/genetics*;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Orthopaedics and Traumatology
2021;34(3):282-287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the analgesic effect of manipulation loading on chronic low back pain (CLBP) model rats and the expression of inflammatory factors in psoas major muscle tissue, and to explore the improvement of manipulation on local inflammatory microenvironment.
METHODS:Thirty two SPF male SD rats weighing 340-360g were randomly divided into blank group, sham operation group, chronic low back pain model group and treatment group, with 8 rats in each group. In the model group, L
RESULTS:There was no significant difference in PWT and PWL between the blank group and the sham operation group after modeling (
CONCLUSION:Local massage loading has analgesic effect on CLBP rats, at the same time, it can inhibit the content of CGRP and NGF in psoas muscle tissue of CLBP rats, and improve the local inflammatory microenvironment.
