Advances about perineuronal nets in the repair of nerve function after spinal cord injury.
10.12200/j.issn.1003-0034.2021.01.017
- Author:
Rong HU
1
;
Hai-Peng XU
1
;
Ke-Lin HE
1
;
Yi CHEN
1
;
Lei WU
1
;
Rui-Jie MA
1
Author Information
1. The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
- Publication Type:Journal Article
- Keywords:
Axons;
Neurons;
Remyelination;
Spinal cord injuries
- MeSH:
Axons;
Extracellular Matrix;
Humans;
Nerve Regeneration;
Neuronal Plasticity;
Neurons;
Spinal Cord;
Spinal Cord Injuries
- From:
China Journal of Orthopaedics and Traumatology
2021;34(1):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Perineuronal nets (PNNs) is a complex network composed of highly condensed extracellular matrix molecules surrounding neurons. It plays an important role in maintaining the performance of neurons and protecting them from harmful substances. However, after spinal cord injury, PNNs forms a physical barrier that surrounds the neuron and limits neuroplasticity, impedes axonal regeneration and myelin formation, and promotes local neuroinflammatory uptake. This paper mainly describes the composition and function of PNNs of neurons and its regulatory effects on axonal regeneration, myelin formation and neuroinflammation after spinal cord injury.
