Research progress on long non-coding RNA (lncRNA) in osteoarthritis.
10.12200/j.issn.1003-0034.2020.11.020
- Author:
Guo-da DAI
1
;
Pei-Min WANG
1
;
Jian-Ping CAI
1
;
Song-He YAN
1
;
Han XIA
1
Author Information
1. Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu, China.
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
RNA, long noncoding;
Review
- MeSH:
Chondrocytes;
Humans;
Osteoarthritis/genetics*;
Quality of Life;
RNA, Long Noncoding/genetics*;
Research
- From:
China Journal of Orthopaedics and Traumatology
2020;33(11):1085-1088
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA) is a common clinical disease. The incidence of OA increases significantly with age, and the quality of life of patients is seriously affected. In the pathogenesis of OA, cartilage degeneration is the main cause. There are many long non-coding RNA (lncRNA) specifically expressed in osteoarthritis, which is closely related to the occurrence and development of osteoarthritis. Based on the latest research from 2014 to 2019, this paper summarizes the differential expression of lncRNA in osteoarthritis, the mechanism of lncRNA regulating chondrocyte function, and the mechanism of lncRNA regulating cartilage matrix metabolism. The fact that the expression of lncRNA is altered at different stages of OA development indicates that lncRNA can be developed forlife. The biomarkers and therapeutic targets can provide reference for the prevention, treatment and research of osteoarthritis.
