Analysis of hemostatic effect of intra-articular injection of tranexamic acid after minimally invasive unicompartmental knee arthroplasty.
10.12200/j.issn.1003-0034.2020.11.016
- Author:
Xiao-Feng WU
1
;
Zi-Fei YIN
1
;
Bin-Feng SUN
1
;
Fan DONG
1
;
Ping-Kang QIAN
1
;
Jing-Bo ZHANG
1
;
Feng XU
1
Author Information
1. Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, Jiangsu, China.
- Publication Type:Journal Article
- Keywords:
Arthroplasty, replacement, knee;
Blood loss, surgical;
Tranexamic acid
- MeSH:
Aged;
Antifibrinolytic Agents/therapeutic use*;
Arthroplasty, Replacement, Knee/adverse effects*;
Blood Loss, Surgical/prevention & control*;
Female;
Hemostatics;
Humans;
Injections, Intra-Articular;
Male;
Middle Aged;
Postoperative Hemorrhage;
Tranexamic Acid
- From:
China Journal of Orthopaedics and Traumatology
2020;33(11):1068-1071
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of intra-articular injection of tranexamic acid on blood loss and blood transfusion rate after minimally invasive unicompartmental knee arthroplasty.
METHODS:From January 2015 to September 2017, 90 patients underwent minimally invasive unicompartmental knee arthroplasty were divided into tranexamic acid group and control group, 45 cases in each group. In the tranexamic acid group, there were 22 males and 23 females, aged 62 to 69 (66.1±2.4) years;in the control group, 20 males and 25 females, aged 63 to 71(68.5±5.2) years. The amount of bleeding in the drainage ball at 48 hours after operation was recorded, and the blood transfusion rate and hematocrit level duringthe perioperative period were recorded. The factors influencing perioperative blood loss included gender, age and body mass index (BMI).
RESULTS:All patients were followed up for 12.5 to 28.3 (22.8±7.9) months. During the follow-up, the wounds of the two groups healed well, and no deep vein thrombosis and pulmonary embolism occurred. There was no significant difference in postoperative blood loss between the tranexamic acid group and the control group. The postoperative bleeding volume in the tranexamic acid group was (110.0±52.1) ml, and that in the control group was (123.0±64.5) ml (P=0.39). There was no blood transfusion in the two groups.
CONCLUSION:Intra articular injection of tranexamic acid can not significantly reduce the postoperative blood loss in patients with minimally invasive unicompartment.
