Efficacy and safety of tranexamic acid in total hip arthroplasty via direct anterior approach.
10.12200/j.issn.1003-0034.2020.11.010
- Author:
Yang ZHANG
1
;
Xiu-Juan QIAN
1
;
Yu-Peng DONG
1
;
Wei-Feng JI
1
;
Jing SHEN
1
Author Information
1. Department of Orthopaedics, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China.
- Publication Type:Journal Article
- Keywords:
Arthroplasty, replacement, hip;
Blood loss, surgical;
Tranexamic acid
- MeSH:
Aged;
Antifibrinolytic Agents/therapeutic use*;
Antiviral Agents;
Arthroplasty, Replacement, Hip/adverse effects*;
Blood Loss, Surgical/prevention & control*;
Female;
Hepatitis C, Chronic;
Humans;
Male;
Middle Aged;
Safety;
Tranexamic Acid/therapeutic use*;
Treatment Outcome
- From:
China Journal of Orthopaedics and Traumatology
2020;33(11):1037-1041
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of local application of tranexamic acid (TXA) in reducing perioperative blood loss in total hip arthroplasty via direct anterior approach (DAA).
METHODS:From July 2013 to September 2018, 46 patients with avascular necrosis of the femoral head were divided into tranexamic acid group (
RESULTS:The incision healed well and no obvious complications occurred in the two groups. All patients were followed up for 12 to 59 months(averaged 31.11 months). No hip pain was found in the follow-up patients. Hip joint function was improved effectively and no prosthesis loosening occurred. The total perioperative blood loss in tranexamic acid group and normal saline group was(740.09±77.14) ml and (1 069.07±113.53) ml respectively, 24 hours after operation, the drainage volume was (87.61±9.28) ml, (233.83±25.62) ml, the hidden blood loss was (409.65±38.01) ml and (588.33±57.16) ml. the difference of hemoglobin before and after operation was (24.78±2.19) g / L and (33.57±2.95) g / L, the difference was statistically significant (
CONCLUSION:local application of tranexamic acid in total hip arthroplasty through direct anterior approach can safely and effectively reduce perioperative blood loss, and does not increase the risk of thrombosis, and does not affect the normal recovery of joint function.
