Wnt5a Plays Controversial Roles in Cancer Progression.

Author: Xu CHEN ¹ ; Hong Ling LIU ² ; Feng Hui ZHAO ¹ ; Zong Xian JIAO ³ ; Jin Sui WANG ¹ ; Ya Mei DANG ¹
Author Information

1. Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China.
2. Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China.
3. Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China.
Publication Type:Journal Article
From: Chinese Medical Sciences Journal 2020;35(4):357-365
CountryChina
Language:English
Abstract: Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. Therefore, it is an essential factor in cancers' progression (invasion, migration, proliferation, and epithelial-mesenchymal transition), and a potential biomarker for prognosis and treatment.