Renal and Gastrointestinal Amyloidosis in Castleman's Disease.
- Author:
So Young CHOI
1
;
Dong Young LEE
;
Kyung Hwan JEONG
;
Joo Young MOON
;
Sang Ho LEE
;
Tea Won LEE
;
Kyung Sam CHO
;
Ju Hee LEE
;
Chun Gyoo IHM
Author Information
1. Department of Internal Medicine, Kyung-Hee University College of Medicine, Seoul, Korea. cgihm@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Castleman's disease;
Plasma cells;
Amyloidosis;
Kidney
- MeSH:
Amyloidosis;
Anemia;
Biopsy;
Diarrhea;
Female;
Giant Lymph Node Hyperplasia;
Humans;
Kidney;
Lymphatic Diseases;
Middle Aged;
Nephrotic Syndrome;
Plasma Cells;
Proteinuria;
Thrombocytopenia;
Weight Loss
- From:Korean Journal of Nephrology
2010;29(2):241-246
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Castleman's disease is a rare disorder and thought to occur as a result of chronic antigenic stimulation due to an unknown infectious or inflammatory etiology. It has a heterogenous course: the symptoms persist in some cases for many years and have a progressive fatal course in others. Renal dysfunction in the form of nephrotic syndrome is quite a rare occurrence. Secondary amyloidosis due to Castleman's disease has also been reported in a few case reports. A 46-year-old female who had asymptomatic abdominal lymphadenopathy was diagnosed with Castleman's disease-plasma cell type in our hospital in 2006. Three years after diagnosis, she developed chronic diarrhea, weight loss, anemia and nephrotic range proteinuria. The etiology of symptom was found to be secondary amyloidosis based on renal and gastrointestinal biopsies. She was discharged with steroid therapy. Unfortunately, she had a progressive fatal course. One month after the treatment, she developed thrombocytopenia and died due to cerebral hemorrhage.
