Low-magnitude vibration promotes osteogenesis of osteoblasts in ovariectomized osteoporotic rats via the estrogen receptor

Author: Guangguang ZHU ¹ ; Xiaoqin YU ¹ ; Jirui WEN ¹ ; Mingyue BAO ¹ ; Min TANG ¹ ; Jingge WANG ¹ ; Xueling HE ² ; Liang LI ¹
Author Information

1. Institute of Biomedical Engineering, West China School of Basic Medical Science & Forensic Medicine, Sichuan University, Chengdu 610041, P.R.China.
2. Laboratory Animal Center, Sichuan University, Chengdu 610041, P.R.China.
Publication Type:Journal Article
Keywords: estrogen receptor α; low-magnitude vibration; osteoblasts; ovariectomized osteoporosis
MeSH: Animals; Cell Differentiation; Estrogen Receptor alpha/genetics*; Female; Osteoblasts; Osteogenesis; Osteoporosis; Ovariectomy; Rats; Vibration
From: Journal of Biomedical Engineering 2020;37(5):825-833
CountryChina
Language:Chinese
Abstract: The purpose of this study was to investigate the effect of low-magnitude vibration on osteogenesis of osteoblasts in ovariectomized rats with osteoporosis via estrogen receptor α(ERα). The mRNA expression of osteogenic markers were examined with qRT-PCR, based on which the optimal vibration parameter for promoting osteogenesis was determined (45 Hz × 0.9 g, g = 9.8 m/s