One new coumarin from seeds of Herpetospermum pedunculosum.
10.19540/j.cnki.cjcmm.20210125.601
- Author:
Dan HUANG
1
;
Ying-Xiong MA
1
;
Lin WEI
1
;
Yan SUN
1
;
Qing-Hong ZENG
1
;
Xiao-Zhong LAN
2
;
Zhi-Hua LIAO
3
;
Min CHEN
1
Author Information
1. College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.
2. College of Food Science, Tibet Agricultural and Animal Husbandry University Nyingchi 860000, China.
3. School of Life Sciences, Southwest University Chongqing 400715, China.
- Publication Type:Journal Article
- Keywords:
Cucurbitaceae;
Herpetospermum pedunculosum;
NO inhibitory activity;
coumarin
- MeSH:
Chromatography, High Pressure Liquid;
Coumarins/pharmacology*;
Cucurbitaceae;
Lignans;
Seeds
- From:
China Journal of Chinese Materia Medica
2021;46(10):2514-2518
- CountryChina
- Language:Chinese
-
Abstract:
This paper aims to investigate the chemical constituents of the seeds of Herpetospermum pedunculosum. One new coumarin and two known lignans were isolated from the ethanolic extract of the seeds of H. pedunculosum with thin layer chromatography(TLC), silica gel column chromatography, Sephedax LH-20 chromatography, Semi-preparative high performance liquid chromatography and recrystallization, etc. Their structures were elucidated as herpetolide H(1), phyllanglaucin B(2), and buddlenol E(3) by analysis of their physicochemical properties and spectral data. Among them, compound 1 was a new compound, and compounds 2 and 3 were isolated from this genus for the first time. In vitro anti-inflammatory activity test showed that herpetolide H had certain NO inhibitory activity for LPS-induced RAW 264.7 cells, with its IC_(50) value of(46.57±3.28) μmol·L~(-1).
