Research progress in mechanism of berberine's antitumor action.
10.19540/j.cnki.cjcmm.20210209.601
- Author:
Xian-Hao YANG
1
;
Li-Jin ZHANG
1
;
Meng-Jun LUO
1
;
Shuai LUO
1
;
Yu-Yuan GONG
1
;
Tao CHEN
1
Author Information
1. Medical College, China Three Gorges University Yichang 443002, China Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University Yichang 443002, China.
- Publication Type:Journal Article
- Keywords:
antitumor;
berberine;
mechanism of action
- MeSH:
Berberine/pharmacology*;
Cell Proliferation;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Neoplasms/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(10):2449-2455
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor, an important factor threatening human life and health, brings huge economic burden to patients. At present, chemoradiotherapy is still the main treatment method for tumor diseases, but there are also great side effects when it plays a therapeutic role. Traditional Chinese medicine in the prevention and treatment of tumor diseases has many advantages such as few side effects, improving the physiological state of patients, and slowing down the side effects of radiotherapy and chemotherapy. Berberine is an effective component of rhizoma coptidis, with a very good antitumor effect. It can inhibit tumor cell proliferation, promote tumor cell apoptosis, inhibit tumor metastasis and angiogenesis, regulate tumor autophagy, reverse multi-drug resistance of tumor, regulate the body immunity, and affect tumor metabolic reprogramming to play its role. Compared with chemical preparations, berberine has a wide range of sources, with high safety and easy access, and has great potential in the prevention and treatment of malignant tumors. In this article, we would mainly review the research progress on the antitumor mechanism of berberine in recent years.